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ASDRP Bioengineering lab research : https://sites.google.com/asdrp.org/pazzi/research?authuser=0
ASDRP Material Science lab research:
https://sites.google.com/asdrp.org/sangeneni/research/treating-neurodegenerative-diseases?authuser=0
Abstract:
In this study, iron oxide nanoparticles (INP) were synthesized using cilantro leaf extract and ferrous sulfate salt. The synthesized INPs were characterized by Fourier-transform infrared spectroscopy (FTIR), Ultraviolet-visible spectroscopy (UV-Vis), and X-ray diffraction (XRD) techniques. XRD showed a crystalline structure with a crystallite size of 42.75 nm, while Scanning Electron Microscopy (SEM) revealed a particle size of 68 nm along with clusters of particles up to 192 nm.
The potential of INPs for treating neurodegenerative diseases was tested using a worm model for Parkinson's disease (WLZ3) using Caenorhabditis elegans (C. elegans) . The worms were exposed to four different concentrations of INPs mixed with DI water: 0.5 mg, 1 mg, 2 mg, and 5 mg/ml. After 48 hours of exposure, the survival rate of wild-type (N2) worms was 50%, 70%, 20%, and 0%, respectively. For the WLZ3 strains, the survival rate was 30%, 30%, 0%, and 0%, respectively.
When the nanoparticles were coated with curcumin, an antioxidant known for its effectiveness against neurodegenerative diseases and anti-inflammatory properties, the survival rate of the WLZ3 strain was 61%, 79%, 64%, and 9%, respectively. The data suggests that there is significant toxicity when the concentration of INPs is greater than 1 mg/ml concentration.
Abstract:
Each year, Americans throw away three million batteries. As per the Environmental Protection Agency, batteries are a leading cause of environmental pollution. Prolonged exposure to the toxic chemicals in batteries causes chronic liver, kidney, lung, and eye diseases. Our objective was to replace the harmful chemicals found in conventional batteries with safer and biodegradable Aloe vera extract. In our experimental setup, copper and zinc electrode pairs were immersed in an Aloe Vera gel extract solution (electrolyte). The electricity generated was due to the oxidation-reduction reaction. A salt bridge balanced the overall charge in the setup. A single Aloe vera cell generated a voltage of 0.97 volts. Connecting two Aloe Vera cells in series doubled the voltage from 0.97 to 1.95 volts. The experiment showed that adding Aloe Vera cells in series as battery packs increased the voltage. Also, the voltage increased as the temperature of the aloe vera increased. At room temperature, the voltage generated was 1.95 volts. Increasing the temperature to 75 degrees Fahrenheit increased the voltage to 2.1 volts, and increasing the temperature to 90 degrees Fahrenheit further increased the voltage to 2.4 volts. Thus, Aloe Vera cells had better battery performance in warmer experimental conditions. We also showed that Aloe Vera is an effective electrolyte solution to drive low-powered digital devices like LEDs and digital clocks. Through this experiment, we successfully constructed and characterized a voltaic cell made of Aloe vera.
Abstract:
Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder in children characterized by symptoms such as lack of attention, forgetfulness, and fidgeting. Neurofeedback is a method that measures brain waves and provides real-time feedback to retrain the brain. The objective of the research was to improve the attention span of children aged 4 to 7 by creating everyday learning tools that integrate real-time neurofeedback from brainwaves. The study involved testing various activities with and without neurofeedback, tracking the effects of different brain waves on attention, and developing learning tools and games as intervention tools for ADHD.
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